منابع مشابه
RB-E2F1 Pathway Regulates Autophagy
ownloade ophagy is a protective mechanism that renders cells viable in stressful conditions. Emerging evidence ts that this cellular process is also a tumor suppressor pathway. Previous studies showed that cyclindent kinase inhibitors (CDKI) induce autophagy. Whether retinoblastoma protein (RB), a key tumor ssor and downstream target of CDKIs, induces autophagy is not clear. Here, we show that ...
متن کاملThe RB-E2F1 pathway regulates autophagy.
Autophagy is a protective mechanism that renders cells viable in stressful conditions. Emerging evidence suggests that this cellular process is also a tumor suppressor pathway. Previous studies showed that cyclin-dependent kinase inhibitors (CDKI) induce autophagy. Whether retinoblastoma protein (RB), a key tumor suppressor and downstream target of CDKIs, induces autophagy is not clear. Here, w...
متن کاملRegulation of the PDK4 isozyme by the Rb-E2F1 complex.
Loss of the transcription factor E2F1 elicits a complex metabolic phenotype in mice underscored by reduced adiposity and protection from high fat diet-induced diabetes. Here, we demonstrate that E2F1 directly regulates the gene encoding PDK4 (pyruvate dehydrogenase kinase 4), a key nutrient sensor and modulator of glucose homeostasis that is chronically elevated in obesity and diabetes and acut...
متن کاملA genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.
The cellular transcription factor E2F appears to be a target for the regulatory action of the retinoblastoma tumor suppressor gene product. The recent isolation of the E2F1 cDNA clone, which encodes a polypeptide with properties characteristic of E2F, has now allowed a more detailed analysis of the regulation of E2F function by Rb as well as the Rb-related p107 protein and the adenovirus 19-kDa...
متن کاملSpecificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb.
The Rb/E2F pathway plays a critical role in the control ofcellular proliferation. Here, we report that E2F1, E2F2, and E2F3 make major individual contributions toward the in vivo phenotypic consequences of Rb deficiency. In the developing lens of Rb(-/-) embryos, loss of E2F1, E2F2, or E2F3 reduces the unscheduled proliferation of fiber cells, with the loss of E2F3 having the most pronounced ef...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2010
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.6.8.13695